A prerequisite for all courses is approval by the course director and the graduate director of the Department of Pharmacology and Toxicology. Graduate students outside the pharmacology program must also have approval of the graduate director of the program in which they are enrolled. Courses are offered annually unless indicated otherwise.
PHARM. 701. SEMINAR. Students are required to (1) attend presentations by others (both faculty and students) participating in the course and (2) make an oral presentation on their own research or an assigned topic. For the former, students are responsible for completing both a written summary and a critique of the presentation. (Required, 1 semester hour)
PHARM. 702. RECENT ADVANCES IN PHARMACOLOGY AND TOXICOLOGY. This course comprises reading, informal presentation and discussion of topics in pharmacology, toxicology and related disciplines from the current scientific literature. Critical evaluation of experimental design, data analysis and interpretation are emphasized. (Required; 1 semester hour)
PHARM. 703. ORIENTATION TO PHARMACOLOGICAL RESEARCH. This course will introduce students to principles of laboratory research and good laboratory practice. The student will participate in discussions with each graduate faculty in the department concerning current research interests and ongoing research projects. (Required; 2 semester hours)
PHARM. 722. PHARMACOLOGY AND THERAPEUTICS. Students are introduced to the principles underlying the use of pharmacological agents in medical practice. Concepts related to drug distribution, drug-receptor interaction and drug metabolism are considered. In addition, the mechanism of action, therapeutic effects, adverse side-effects and common clinical applications of various drugs and drug classes are presented through a combination of lectures and clinical correlations. (Elective, 12 semester hours, 6-6)
PHARM. 723. MECHANISMS OF DRUG ACTION. This course comprises assigned readings, in-class discussions, written assignments and student presentations. Selected aspects of pharmacology are presented with emphasis on the mechanisms of drug action. (Required; 4 semester hours)
PHARM 726. PHARMACOLOGY. A basic pharmacology course in which principles underlying the actions of drugs are presented, including pharmacokinetics, drug-receptor interactions, and drug metabolism. In addition, mechanisms of action, therapeutic effects, adverse effects and therapeutic indications are noted for major classes of drugs and for commonly used drugs within each class. (Required; 4 semester hours) (also listed as Dental 626).
PHARM. 780. CNS PHARMACOLOGY. Drug actions at neuronal targets, the blood-brain barrier and special pharmacokinetics of centrally acting drugs, and the pharmacotherapy of the CNS and neurological disorders are among the topics covered. [Co-listed as Pharmacological Neuroscience, NSCI. 706]. (Elective, 3 semester hours)
PHARM. 781. MOLECULAR TOXICOLOGY. This is a reading and discussion-based class. The molecular mechanisms of several toxicant classes are covered. Emphasis is placed on the effects of xenobiotics on cellular processes, including biochemical reactions and signaling pathways. (Elective; 2 semester hours)
PHARM. 782. DRUG ABUSE. This course describes drugs that are abused, biological aspects of abuse, patterns of abuse, and theories of drug tolerance and dependence. (Elective; 2 semester hours)
PHARM. 784. CIRCULATORY PHARMACOLOGY. This course involves a study of normal circulatory mechanisms and functions and how various drugs and toxic substances modify them. (Elective; 2 semester hours)
PHARM. 785. PRINCIPLES OF MODERN DRUG DESIGN. This course addresses the basic principles of the modern drug discovery and validation process, with emphasis on applications in cancer therapy. The course begins with the identification and characterization of disease-specific molecular targets using genetic and biochemical techniques. The second section describes the selection of lead drugs through high-throughput screening assays, combinatorial chemistry, and computer-assisted rational drug design. The final section covers preclinical and clinical trials and the potential use of database analysis to ensure that the drugs are safe and effective, and that the chosen therapeutic regimen will yield the best outcome for any given patient. (Elective; 2 semester hours)
PHARM. 786. PHARMACOLOGY OF SYNAPTIC TRANSMISSION. The course focuses on the mechanisms of synaptic transmission in autonomic ganglia and at peripheral neuroeffector junctions. Emphasis is placed on the pre-and post-synaptic processes regulating neurotransmission at these peripheral synapses. The roles of synaptic proteins, and classical and non-classical transmitters are explored in detail. As time permits, clinical examples of the effects of failures in peripheral synaptic transmission are presented. (Elective; 2 semester hours)
PHARM. 790. SPECIAL TOPICS IN PHARMACOLOGY AND TOXICOLOGY. This course may cover any area of interest to at least one student and one faculty member. (Elective; Hours/credit TBA)
PHARM. 792. RESEARCH IN PHARMACOLOGY AND TOXICOLOGY. Students perform research in the laboratory of a faculty member. Students are also required to make a 20-30 presentation concerning the rotation [including the general premise, experimental approach and results; the latter two may be actual or anticipated] within 4-6 wks of its completion. (Required; 3 semester hours)
PHARM. 798. DISSERTATION AND DISSERTATION RESEARCH (Required; Hours/credit TBA)
PHARM. 799. THESIS AND THESIS RESEARCH. (Hours/credit TBA)
CURRICULUM
Core component
Required Pharmacology and Toxicology Courses
PHARM701 Seminar
PHARM702 Recent Advances in Pharmacology and Toxicology (student journal club)
PHARM703 Orientation to Pharmacological Research
PHARM726 Pharmacology or PH722 Pharmacology and Therapeutics
PHARM723 Mechanisms of Drug Action
PHARM792 Research Rotations (minimum of 2)
PHARM780 series or equivalent from another department (minimum of 2)
Required Support Courses
BIOCH704 Biochemistry
PHYSIO725 Physiology
Required Interdisciplinary Core Courses
ID704 An Introduction to Animal Research
ID709 Responsible Conduct of Research (SOGS)
ID710 Research Tools in Molecular Biology (SOGS)
ID714 Professional Skills for Graduate Students and Postdoctoral Fellows (SOGS)
PM740 Statistical Methods in Research or CHS701 Biostatistics (SOGS)
Elective component
Electives in Pharmacology and Toxicology
PHARM780 CNS Pharmacology
PHARM781 Molecular Toxicology
PHARM782 Drug Abuse
PHARM784 Circulatory Pharmacology
PHARM785 Principles of Modern Drug Design
PHARM786 Autonomic Pharmacology
PHARM790 Special topics, taken in conjunction with PHARM792 (Research Rotation) or offered on request
Recommended Electives offered by other Graduate Departments
ID715 Teaching in Higher Education
Dissertation/Thesis
PHARM798 Dissertation and Dissertation Research
PHARM799 Thesis and Thesis Research