Arthur S. Hume, Ph.D.
Professor Emeritus
Research 401
(601) 984-1612
AHume@pharmacology.umsmed.edu
Current Research
The research in my laboratory involves studies into various toxicological problems.
Analyses of drugs and other chemicals from biological tissue are a mainstay of our research. These analyses are accomplished by the use of high performance liquid chromatography, thin layer chromatography and gas chromatography, immunoassay, atomic absorption and visible ultraviolet spectrophotometry. These analytical capabilities are being utilized in collaboration in both basic and clinical research problems in which detection and/or quantitation of various drugs and chemicals are required.
Presently, our principle efforts are directed towards investigations into the possible agents associated with Gulf War Illness. Primarily, the interactions of pyridostigmine with the insect repellent, N,N,m-diethyl-toluamide (DEET), adrenergic agents and caffeine are being studied. Recently, we have found that there is a synergistic relationship between pyridostigmine, and DEET and caffeine. Elucidation of the mechanism of these interactions is in progress. These studies will involve toxicokinetics, enzyme inhibition, monitoring of cardiovascular effects, cell proliferation in the immune system and behavioral effects.
Selected Publications
Moore, S. J., Porter, A. C., Ezell, A. E., Hume, A. S. and Ho, I. K. The rapid determination of ethanol in post mortem brain samples by solvent extraction and gas chromatography. J. Food Drug Anal. 1(3): 245-249, 1993.
Hume, A. S., Mozingo, J. R., McIntyre, B. and Ho, I. K. Antidotal efficacy of a -ketoglutaric acid and sodium thiosulfate in cyanide poisoning. J. Tox-Clin. Tox. 33: 721-724, 1995. 
Rockhold, R., Carlton, F., Corkern, R., Derouen, L., Bennett, J. and Hume, A. S. Methcathinone intoxication in the rat: abrogation by dextrorphan. Ann. Emerg. Med. 29: 383-391, 1997.
Chaney, L., Rockhold, R., Mozingo, J., Hume, A. S. and Moss, J.I. Potentiation of pyridostigmine bromide toxicity in mice by selected adrenergic agents and caffeine. Vet. Human Toxicol., 39:214-219, 1997.