Jerry M. Farley, Ph.D.
Professor and Interim Chair
Guyton 325
(601) 984-1630
jfarley@pharmacology.umsmed.edu

Current Research

Mucus secretion and water transport by airway epithelium is a very important process. Pathophysiological changes in secretions occur in diseases such as asthma and cystic fibrosis. One focus of my laboratory is to understand the mechanisms of water and mucus secretions from airway submucousal gland cells. The secretagogue-induced increases in both mucus release and water secretion are being explored using electrophysiological (Ussing and Patch clamp), cell biological (single cell calcium imaging) and various biochemical and molecular biological techniques to understand the relationship between ion/water secretion and mucus release in isolated gland cells grown in tissue culture. In addition, cellular processes that lead to sensitization of these responses to acetylcholine and histamine are being studied as one possible mechanism for development of hypersecretion as observed in asthma and other disease states.

Selected Publications

Farley, J.M., Adderholt, J.G., Dwyer, T.M. Cocaine and tracheal epithelial function: effects on short circuit current and neurotransmitter receptors. J Pharmacol. Exp. Ther. 259(1):241-7, 1991 .

Dwyer, T. M. and Farley, J.M. Mucus glycoconjugate secretion in cool and hypertonic solutions. Am. J. Physiol. 272 (Lung Cell. Mol. Physiol. 16): L1121-L1125, 1997.

Chan, M.-H., and Farley, J.M. Lidocaine-induced alterations in agonist-induced ion transport of cultured swine tracheal submucosal gland cells. Toxicol. Appl. Pharmacol. 167: 231-236, 2000.

Dwyer, T. M. and Farley, J.M. Human neutrophil elastase releases two pools of mucinlike glycoconjugate from tracheal submucosal gland cells. Am. J Physiol. Lung Cell Mol. Physiol. 278: L675-L236, 2000.

Mamoon, A.M., Baker, R.C. and Farley, J.M. Activation of phospholipase D in porcine tracheal smooth muscle: role of phosphatidylinositol 3-kinase and RhoA activation. Europ. J. Pharmacol. 433: 7-16, 2001.

Liu, H. and Farley, J. Prostanoids secreted by alveolar macrophages enhance ionic currents in swine tracheal submucosal glands. J. Pharmacol. Exp. Ther. 31: 729-739, 2005.

Liu, H. and Farley, J.M. Effects of first and second generation antihistamines on muscarinic induced mucus gland cell ion transport. BMC Pharmacol. 5: 8, 2005.

Liu, H., Q. Zheng, and J.M. Farley, "Antimuscarinic actions of antihistamines on the heart". J Biomed Sci, 2006. 13(3): p. 395-401.  PMID#16453179 

Chung, W.S. and J.M. Farley, "Tachyphylaxis to the inhibitory effect of L-type channel blockers on ACh-induced [Ca2+]i oscillations in porcine tracheal myocytes". J Biomed Sci, 2007. 14(1): p. 129-43.  PMID#17278012 

Liu, H. and J.M. Farley, Sr., "Prostaglandin E2 enhances acetylcholine-induced, Ca2+-dependent ionic currents in swine tracheal mucous gland cells". J Pharmacol Exp Ther, 2007. 322(2): p. 501-13.  PMID#17483294