Mass Spectrometry Core                

The Mass Spectrometry Core provides quantitative analysis for drug metabolism studies, including the identification and structure elucidation of metabolites for many drugs.  Biological lipids, both neutral lipids and phospholipids, can be measured and we have experience in measuring steroid hormones.  We can determine the molecular weight of peptides and proteins up to a molecular weight of about 100,000 Daltons, and if a suitable standard is available, the concentration of lower molecular weight peptides can be measured.

The core facility has:

• a gas liquid chromatography /single quadrupole mass spectrometer,

• an ABI/PSCIEX365 liquid chromatography/triple quadrupole mass spectrometer

We have the necessary instrumentation and experience to provide the analytical requirements for many pharmacokinetic studies and for measuring the molecular weight of isolated or partially isolated peptides and proteins. 

New equipment anticipated:

• an ABI 4000 QTRAP, anticipated by 2009 year’s end

• an ABI 3000 triple quad, also anticipated in early 2010

Arrangements for handling samples will be determined for each individual analysis.  We can provide assistance in the extraction and derivatization of analytes, and sample preparation, if necessary.

Richard Roman, PhD, Mass Spectrometry Core Director                          601-984-1602

Naila Mamoon, PhD, Mass Spectrometry Core Manager                          601-984-1634

Rodney C. Baker, PhD, Mass Spectrometry Core Consultant                    601-984-1620

Chris Purser, GCMS Specialist                                                                 601-984-1616

Located in R416 and R414